Nature Communications (Aug 2022)
SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells
- Eva M. Stevenson,
- Sandra Terry,
- Dennis Copertino,
- Louise Leyre,
- Ali Danesh,
- Jared Weiler,
- Adam R. Ward,
- Pragya Khadka,
- Evan McNeil,
- Kevin Bernard,
- Itzayana G. Miller,
- Grant B. Ellsworth,
- Carrie D. Johnston,
- Eli J. Finkelsztein,
- Paul Zumbo,
- Doron Betel,
- Friederike Dündar,
- Maggie C. Duncan,
- Hope R. Lapointe,
- Sarah Speckmaier,
- Nadia Moran-Garcia,
- Michelle Premazzi Papa,
- Samuel Nicholes,
- Carissa J. Stover,
- Rebecca M. Lynch,
- Marina Caskey,
- Christian Gaebler,
- Tae-Wook Chun,
- Alberto Bosque,
- Timothy J. Wilkin,
- Guinevere Q. Lee,
- Zabrina L. Brumme,
- R. Brad Jones
Affiliations
- Eva M. Stevenson
- Department of Medicine, Weill Cornell Medical College
- Sandra Terry
- Department of Medicine, Weill Cornell Medical College
- Dennis Copertino
- Department of Medicine, Weill Cornell Medical College
- Louise Leyre
- Department of Medicine, Weill Cornell Medical College
- Ali Danesh
- Department of Medicine, Weill Cornell Medical College
- Jared Weiler
- Department of Medicine, Weill Cornell Medical College
- Adam R. Ward
- Department of Medicine, Weill Cornell Medical College
- Pragya Khadka
- Department of Medicine, Weill Cornell Medical College
- Evan McNeil
- Department of Medicine, Weill Cornell Medical College
- Kevin Bernard
- Department of Medicine, Weill Cornell Medical College
- Itzayana G. Miller
- Department of Medicine, Weill Cornell Medical College
- Grant B. Ellsworth
- Department of Medicine, Weill Cornell Medical College
- Carrie D. Johnston
- Department of Medicine, Weill Cornell Medical College
- Eli J. Finkelsztein
- Department of Medicine, Weill Cornell Medical College
- Paul Zumbo
- Applied Bioinformatics Core, Weill Cornell Medical College
- Doron Betel
- Department of Medicine, Weill Cornell Medical College
- Friederike Dündar
- Applied Bioinformatics Core, Weill Cornell Medical College
- Maggie C. Duncan
- Faculty of Health Sciences, Simon Fraser University
- Hope R. Lapointe
- British Columbia Centre for Excellence in HIV/AIDS
- Sarah Speckmaier
- British Columbia Centre for Excellence in HIV/AIDS
- Nadia Moran-Garcia
- British Columbia Centre for Excellence in HIV/AIDS
- Michelle Premazzi Papa
- Dept of Microbiology Immunology and Tropical Medicine, The George Washington University
- Samuel Nicholes
- Dept of Microbiology Immunology and Tropical Medicine, The George Washington University
- Carissa J. Stover
- Dept of Microbiology Immunology and Tropical Medicine, The George Washington University
- Rebecca M. Lynch
- Dept of Microbiology Immunology and Tropical Medicine, The George Washington University
- Marina Caskey
- Laboratory of Molecular Immunology, The Rockefeller University
- Christian Gaebler
- Laboratory of Molecular Immunology, The Rockefeller University
- Tae-Wook Chun
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID, NIH
- Alberto Bosque
- Dept of Microbiology Immunology and Tropical Medicine, The George Washington University
- Timothy J. Wilkin
- Department of Medicine, Weill Cornell Medical College
- Guinevere Q. Lee
- Department of Medicine, Weill Cornell Medical College
- Zabrina L. Brumme
- Faculty of Health Sciences, Simon Fraser University
- R. Brad Jones
- Department of Medicine, Weill Cornell Medical College
- DOI
- https://doi.org/10.1038/s41467-022-32376-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Here, the authors show in a cohort of people with HIV, COVID mRNA vaccination is followed by a transient boost in a particular profile of HIV-specific T-cell responses and a corresponding decrease in residual HIV RNA – suggesting productive immune engagement with infected cells.
