Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration

Fujian Zhao; Xiongfa Ji; Yang Yan; Yang Yan; Zhen Yang; Zhen Yang; Xiaofeng Chen; Xiaofeng Chen; Limin Ma

doi:10.3389/fmats.2021.701268

Frontiers in Materials (Nov 2021)

Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration

Fujian Zhao,
Xiongfa Ji,
Yang Yan,
Yang Yan,
Zhen Yang,
Zhen Yang,
Xiaofeng Chen,
Xiaofeng Chen,
Limin Ma

Affiliations

Fujian Zhao: Stomatological Hospital, Southern Medical University, Guangzhou, China
Xiongfa Ji: Department of Orthopedics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Yang Yan: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Yang Yan: National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, China
Zhen Yang: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Zhen Yang: National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, China
Xiaofeng Chen: Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Xiaofeng Chen: National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, China
Limin Ma: Department of Orthopedics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

DOI: https://doi.org/10.3389/fmats.2021.701268
Journal volume & issue: Vol. 8

Abstract

Read online

The repair of bone defects in load-bearing positions still faces great challenges. Tantalum (Ta) has attempted to repair bone defects based on the excellent mechanical properties. However, the osseointegration of Ta needs to be improved due to the lack of osteoinduction. Herein, tantalum–gelatin–methacryloyl–bioactive glass (Ta–GelMA–BG) scaffolds were successfully fabricated by loading BG in 3D-printed Ta scaffolds through a chemical crosslinking method. The results showed that the composite scaffolds have the ability to promote cell adhesion and proliferation. The incorporation of BG resulted in a significant increase in apatite-forming and osteogenesis differentiation abilities. In vivo results indicated that the Ta–GelMA–BG scaffolds significantly enhanced the osteointegration at the early stage after implantation. Overall, the Ta–GelMA–BG scaffolds are a promising platform for the load bearing bone regeneration field.

Published in Frontiers in Materials

ISSN: 2296-8016 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology
Website: https://www.frontiersin.org/journals/materials

About the journal

Abstract

Keywords