RETRACTED: The application of hierarchy MoS2 particles for NIR induced drug delivery towards liver cancer treatment

Abstract

This paper applied hierarchy MoS _2 particles for near-infrared induced drug delivery towards liver cancer treatment. MoS _2 particles were used as the photothermal responsive agent, 1-tetradecanol was used as the phase change material, doxorubicin was encapsulated into the particles, and MoS _2 /1-tetradecanol@doxorubicin composite was synthesized. The drug release was tested under near-infrared irradiation. Within the MoS _2 /1-tetradecanol@doxorubicin composite, the photothermal response of MoS _2 to near-infrared facilitated the phase change of 1-tetradecanol and the release of doxorubicin. The release of doxorubicin could be regulated by both the MoS _2 concentration and the irradiation power. The cytotoxicity study indicated that MoS _2 /1-tetradecanol had negligible toxicity to the HepG2 cells, while MoS _2 /1-tetradecanol@doxorubicin had more tumor-killing effects than free doxorubicin. This research showed that hierarchy MoS _2 particles had the potential of delivering anti-tumor drugs through photothermal stimuli.

Keywords

• MoS2 particles
• near-infrared irradiation
• photothermal
• drug delivery
• doxorubicin
• 1-tetradecanol