EuPA Open Proteomics (Mar 2016)

Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype

  • Laura Giusti,
  • Federica Ciregia,
  • Alessandra Bonotti,
  • Ylenia Da Valle,
  • Elena Donadio,
  • Claudia Boldrini,
  • Rudy Foddis,
  • Gino Giannaccini,
  • Maria R. Mazzoni,
  • Pier Aldo Canessa,
  • Alfonso Cristaudo,
  • Antonio Lucacchini

DOI
https://doi.org/10.1016/j.euprot.2016.01.006
Journal volume & issue
Vol. 10, no. C
pp. 42 – 49

Abstract

Read online

Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes.

Keywords