Research progress on the role of exosomes in renal interstitial fibrosis

Abstract

Chronic kidney disease （CKD） has become a global public health event. CKD may eventually progress into end-stage renal disease （ESRD）. Renal interstitial fibrosis （RIF） is the common pathway for the progression from CKD into ESRD. Due to the complex pathogenesis, there is currently no effective treatment for RIF. Recent studies have shown that exosomes play an important role in the occurrence and development of a variety of kidney diseases. In this article, the latest research progress on the role of exosomes in the pathogenesis of RIF was reviewed, and the application prospect of exosomes in the diagnosis and treatment of RIF was investigated.

Keywords

• |renal interstitial fibrosis|exosome|pathogenesis|artificial exosome