Recent Progress Concerning the <i>N</i>-Arylation of Indoles

Abstract

This review summarizes the current state-of-the-art procedures in terms of the preparation of N-arylindoles. After a short introduction, the transition-metal-free procedures available for the N-arylation of indoles are briefly discussed. Then, the nickel-catalyzed and palladium-catalyzed N-arylation of indoles are both discussed. In the next section, copper-catalyzed procedures for the N-arylation of indoles are described. The final section focuses on recent findings in the field of biologically active N-arylindoles.

Keywords

• <i>N</i>-arylation
• indole
• Buchwald–Hartwig amination
• Ullmann condensation
• Chan–Lam coupling