Neutrophils: New Critical Regulators of Glioma

Guanyu Wang; Jinpeng Wang; Chaoshi Niu; Chaoshi Niu; Chaoshi Niu; Chaoshi Niu; Yan Zhao; Pengfei Wu; Pengfei Wu; Pengfei Wu; Pengfei Wu; Pengfei Wu

doi:10.3389/fimmu.2022.927233

Frontiers in Immunology (Jul 2022)

Neutrophils: New Critical Regulators of Glioma

Guanyu Wang,
Jinpeng Wang,
Chaoshi Niu,
Chaoshi Niu,
Chaoshi Niu,
Chaoshi Niu,
Yan Zhao,
Pengfei Wu,
Pengfei Wu,
Pengfei Wu,
Pengfei Wu,
Pengfei Wu

Affiliations

Guanyu Wang: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Jinpeng Wang: Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Chaoshi Niu: Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
Chaoshi Niu: Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, China
Chaoshi Niu: Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, China
Chaoshi Niu: Anhui Provincial Clinical Research Center for Neurosurgical Disease, Hefei, China
Yan Zhao: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Pengfei Wu: Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
Pengfei Wu: Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, China
Pengfei Wu: Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, China
Pengfei Wu: Anhui Provincial Clinical Research Center for Neurosurgical Disease, Hefei, China
Pengfei Wu: Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, China

DOI: https://doi.org/10.3389/fimmu.2022.927233
Journal volume & issue: Vol. 13

Abstract

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In cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous studies have shown that circulating and infiltrating neutrophils are associated with malignant progression and immunosuppression in gliomas. However, recent studies have shown that neutrophils have an antitumour effect. In this review, we focus on the functional roles of neutrophils in the circulation and tumour sites in patients with glioma. The mechanisms of neutrophil recruitment, immunosuppression and the differentiation of neutrophils are discussed. Finally, the potential of neutrophils as clinical biomarkers and therapeutic targets is highlighted. This review can help us gain a deeper and systematic understanding of the role of neutrophils, and provide new insights for treatment in gliomas.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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