Communications Biology (May 2021)
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
- Xuling Chang,
- Resham L. Gurung,
- Ling Wang,
- Aizhen Jin,
- Zheng Li,
- Renwei Wang,
- Kenneth B. Beckman,
- Jennifer Adams-Haduch,
- Wee Yang Meah,
- Kar Seng Sim,
- Weng Khong Lim,
- Sonia Davila,
- Patrick Tan,
- Jing Xian Teo,
- Khung Keong Yeo,
- Yiamunaa M.,
- Sylvia Liu,
- Su Chi Lim,
- Jianjun Liu,
- Rob M. van Dam,
- Yechiel Friedlander,
- Woon-Puay Koh,
- Jian-Min Yuan,
- Chiea Chuen Khor,
- Chew-Kiat Heng,
- Rajkumar Dorajoo
Affiliations
- Xuling Chang
- Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
- Resham L. Gurung
- Clinical Research Unit, Khoo Teck Puat Hospital
- Ling Wang
- Genome Institute of Singapore, Agency for Science, Technology, and Research
- Aizhen Jin
- Health Services and Systems Research, Duke-NUS Medical School Singapore
- Zheng Li
- Genome Institute of Singapore, Agency for Science, Technology, and Research
- Renwei Wang
- Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh
- Kenneth B. Beckman
- University of Minnesota Genomics Center, University of Minnesota
- Jennifer Adams-Haduch
- Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh
- Wee Yang Meah
- Genome Institute of Singapore, Agency for Science, Technology, and Research
- Kar Seng Sim
- Genome Institute of Singapore, Agency for Science, Technology, and Research
- Weng Khong Lim
- SingHealth Duke-NUS Institute of Precision Medicine
- Sonia Davila
- SingHealth Duke-NUS Institute of Precision Medicine
- Patrick Tan
- Genome Institute of Singapore, Agency for Science, Technology, and Research
- Jing Xian Teo
- SingHealth Duke-NUS Institute of Precision Medicine
- Khung Keong Yeo
- SingHealth Duke-NUS Institute of Precision Medicine
- Yiamunaa M.
- Clinical Research Unit, Khoo Teck Puat Hospital
- Sylvia Liu
- Clinical Research Unit, Khoo Teck Puat Hospital
- Su Chi Lim
- Clinical Research Unit, Khoo Teck Puat Hospital
- Jianjun Liu
- Genome Institute of Singapore, Agency for Science, Technology, and Research
- Rob M. van Dam
- Saw Swee Hock School of Public Health, National University of Singapore
- Yechiel Friedlander
- School of Public Health and Community Medicine, Hebrew University of Jerusalem
- Woon-Puay Koh
- Health Services and Systems Research, Duke-NUS Medical School Singapore
- Jian-Min Yuan
- Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh
- Chiea Chuen Khor
- Genome Institute of Singapore, Agency for Science, Technology, and Research
- Chew-Kiat Heng
- Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
- Rajkumar Dorajoo
- Genome Institute of Singapore, Agency for Science, Technology, and Research
- DOI
- https://doi.org/10.1038/s42003-021-02056-7
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 9
Abstract
Xuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leukocyte telomere length and report a mechanistic pathway linking TERF1, leukocyte telomere length and incident colon cancer.
