Nature Communications (Mar 2019)
Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
- Santanu Adhikary,
- Deepavali Chakravarti,
- Christopher Terranova,
- Isha Sengupta,
- Mayinuer Maitituoheti,
- Anirban Dasgupta,
- Dushyant Kumar Srivastava,
- Junsheng Ma,
- Ayush T. Raman,
- Emily Tarco,
- Aysegul A. Sahin,
- Roland Bassett,
- Fei Yang,
- Coya Tapia,
- Siddhartha Roy,
- Kunal Rai,
- Chandrima Das
Affiliations
- Santanu Adhikary
- Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics
- Deepavali Chakravarti
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Christopher Terranova
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Isha Sengupta
- Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics
- Mayinuer Maitituoheti
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Anirban Dasgupta
- Structural Biology and Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology
- Dushyant Kumar Srivastava
- Structural Biology and Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology
- Junsheng Ma
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Ayush T. Raman
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Emily Tarco
- Department of Translational Molecular Pathology and Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center
- Aysegul A. Sahin
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Roland Bassett
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Fei Yang
- Department of Translational Molecular Pathology and Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center
- Coya Tapia
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Siddhartha Roy
- Structural Biology and Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology
- Kunal Rai
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Chandrima Das
- Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics
- DOI
- https://doi.org/10.1038/s41467-019-08986-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
H2B monoubiquitination is implicated in oncogenesis. Here, the authors show that UBR7 PHD finger is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene expression for EMT, while promoting expression of CDH4 which restrain WNT/β-cat pathway.
