Nature Communications (Jun 2021)
Human cytomegalovirus-induced host protein citrullination is crucial for viral replication
- Gloria Griffante,
- Francesca Gugliesi,
- Selina Pasquero,
- Valentina Dell’Oste,
- Matteo Biolatti,
- Ari J. Salinger,
- Santanu Mondal,
- Paul R. Thompson,
- Eranthie Weerapana,
- Robert J. Lebbink,
- Jasper A. Soppe,
- Thomas Stamminger,
- Virginie Girault,
- Andreas Pichlmair,
- Gábor Oroszlán,
- Donald M. Coen,
- Marco De Andrea,
- Santo Landolfo
Affiliations
- Gloria Griffante
- Department of Public Health and Pediatric Sciences, University of Turin
- Francesca Gugliesi
- Department of Public Health and Pediatric Sciences, University of Turin
- Selina Pasquero
- Department of Public Health and Pediatric Sciences, University of Turin
- Valentina Dell’Oste
- Department of Public Health and Pediatric Sciences, University of Turin
- Matteo Biolatti
- Department of Public Health and Pediatric Sciences, University of Turin
- Ari J. Salinger
- Department of Biochemistry and Molecular Pharmacology, UMass Medical School
- Santanu Mondal
- Department of Biochemistry and Molecular Pharmacology, UMass Medical School
- Paul R. Thompson
- Department of Biochemistry and Molecular Pharmacology, UMass Medical School
- Eranthie Weerapana
- Department of Chemistry, Boston College
- Robert J. Lebbink
- Department of Medical Microbiology, University Medical Center Utrecht
- Jasper A. Soppe
- Department of Medical Microbiology, University Medical Center Utrecht
- Thomas Stamminger
- Institute of Virology, Ulm University Medical Center
- Virginie Girault
- Institute of Virology, Technical University of Munich
- Andreas Pichlmair
- Institute of Virology, Technical University of Munich
- Gábor Oroszlán
- Department of Biological Chemistry & Molecular Pharmacology, Blavatnik Institute, Harvard Medical School
- Donald M. Coen
- Department of Biological Chemistry & Molecular Pharmacology, Blavatnik Institute, Harvard Medical School
- Marco De Andrea
- Department of Public Health and Pediatric Sciences, University of Turin
- Santo Landolfo
- Department of Public Health and Pediatric Sciences, University of Turin
- DOI
- https://doi.org/10.1038/s41467-021-24178-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired in RNA binding, as a potential mechanism of evasion.
