Nature and Science of Sleep (Aug 2022)

Independent Association Between Oxygen Desaturation Index and Cardiovascular Disease in Non-Sleepy Sleep-Disordered Breathing Subtype: A Chinese Community-Based Study

  • Wang L,
  • Ou Q,
  • Shan G,
  • Lao M,
  • Pei G,
  • Xu Y,
  • Huang J,
  • Tan J,
  • Chen W,
  • Lu B

Journal volume & issue
Vol. Volume 14
pp. 1397 – 1406

Abstract

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Longlong Wang,1,2 Qiong Ou,1,2 Guangliang Shan,3 Miaochan Lao,2 Guo Pei,2 Yanxia Xu,2 Jinhuan Huang,4 Jiaoying Tan,1,2 Weiping Chen,1,2 Bing Lu1,2 1The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 2Sleep Center, Department of Pulmonary and Critical Care Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou, People’s Republic of China; 3Department of Epidemiology & Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, People’s Hospital of Chenghai, Shantou, People’s Republic of ChinaCorrespondence: Qiong Ou, Sleep Center, Department of Pulmonary and Critical Care Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou, 510080, People’s Republic of China, Tel +86 13609717251, Email [email protected]: Non-sleepy sleep-disordered breathing (SDB) is increasingly recognized as an important clinical subtype. The association between non-sleepy SDB and cardiovascular disease (CVD) is not well understood. Our objectives were to investigate the relationship between non-sleepy SDB and CVD and determine which nocturnal hypoxia parameter most strongly reflects this association in a large community population.Patients and Methods: Cross-sectional data from 3626 randomly-selected Chinese community-dwelling participants who underwent overnight type IV sleep monitoring were analyzed. Parameters of nocturnal hypoxemia were extracted from sleep monitoring devices, including mean nocturnal oxygen saturation, lowest oxygen saturation, oxygen desaturation index (ODI), and time with oxygen saturation < 90%. An ODI ≥ 7.0 events/h was considered to signify SDB. An Epworth Sleepiness Scale score of 10 or less indicated no sleepiness.Results: The SDB rate was 30.7% (1114/3626), of which 96.5% (1075/1114) were considered the non-sleepy SDB subtype. ODI, typical nocturnal intermittent hypoxia indicator for SDB, was independently related to CVD, regardless of whether excessive daytime sleepiness was present. After adjusting for confounders, ODI most strongly reflected the association between non-sleepy SDB and CVD (OR:1.023; 95% CI:1.003– 1.043). We observed a nonlinear association between ODI and the prevalence of CVD, where the likelihood of CVD increased with ODI≥ 10 events/h and a markedly increasing trend was observed with ODI ≥ 20 events/h (reference ODI = 7.0 events/h). Metabolic parameters, Pittsburgh Sleep Quality Index, and inflammatory marker did not mediate the association between ODI and CVD in the non-sleepy SDB subtype.Conclusion: In the Chinese community-dwelling population, non-sleepy SDB was highly prevalent. ODI, an easily extracted indicator from a type IV sleep monitor, most strongly reflected the association between non-sleepy SDB and CVD.Keywords: oxygen desaturation index, cardiovascular disease, non-sleepy, sleep-disordered breathing, community-based general population

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