Nature Communications (Feb 2022)
Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain
- Shannon Tansley,
- Sonali Uttam,
- Alba Ureña Guzmán,
- Moein Yaqubi,
- Alain Pacis,
- Marc Parisien,
- Haley Deamond,
- Calvin Wong,
- Oded Rabau,
- Nicole Brown,
- Lisbet Haglund,
- Jean Ouellet,
- Carlo Santaguida,
- Alfredo Ribeiro-da-Silva,
- Soroush Tahmasebi,
- Masha Prager-Khoutorsky,
- Jiannis Ragoussis,
- Ji Zhang,
- Michael W. Salter,
- Luda Diatchenko,
- Luke M. Healy,
- Jeffrey S. Mogil,
- Arkady Khoutorsky
Affiliations
- Shannon Tansley
- Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University
- Sonali Uttam
- Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University
- Alba Ureña Guzmán
- Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University
- Moein Yaqubi
- Neuroimmunology Unit, Montreal Neurological Institute, McGill University
- Alain Pacis
- Canadian Centre for Computational Genomics, McGill Genome Centre
- Marc Parisien
- Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University
- Haley Deamond
- Department of Pharmacology and Therapeutics, McGill University
- Calvin Wong
- Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University
- Oded Rabau
- McGill Scoliosis and Spine Group, Department of Surgery, McGill University
- Nicole Brown
- Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University
- Lisbet Haglund
- The Orthopaedic Research Laboratory, Department of Surgery, McGill University
- Jean Ouellet
- McGill Scoliosis and Spine Group, Department of Surgery, McGill University
- Carlo Santaguida
- Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University
- Alfredo Ribeiro-da-Silva
- Alan Edwards Centre for Research on Pain, McGill University
- Soroush Tahmasebi
- Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago
- Masha Prager-Khoutorsky
- Department of Physiology, McGill University
- Jiannis Ragoussis
- Department of Human Genetics and Department of Bioengineering, McGill University
- Ji Zhang
- Alan Edwards Centre for Research on Pain, McGill University
- Michael W. Salter
- Neurosciences & Mental Health Program, Hospital for Sick Children, Department of Physiology, Faculty of Medicine, University of Toronto
- Luda Diatchenko
- Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University
- Luke M. Healy
- Neuroimmunology Unit, Montreal Neurological Institute, McGill University
- Jeffrey S. Mogil
- Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University
- Arkady Khoutorsky
- Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences, McGill University
- DOI
- https://doi.org/10.1038/s41467-022-28473-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Microglia subpopulations may differentially contribute to pain. Here, the authors show that peripheral nerve injury induces time- and sex-specific transcriptional changes in mouse spinal cord microglia subpopulations and that ApoE is linked to neuropathic pain hypersensitivity in mice and humans.
