Nature Communications (Mar 2016)

Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

  • Benjamin Cao,
  • Zhen Zhang,
  • Jochen Grassinger,
  • Brenda Williams,
  • Chad K. Heazlewood,
  • Quentin I. Churches,
  • Simon A. James,
  • Songhui Li,
  • Thalia Papayannopoulou,
  • Susan K. Nilsson

DOI
https://doi.org/10.1038/ncomms11007
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model.