Nature Communications (Sep 2022)
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
- Dongni Shi,
- Xianqiu Wu,
- Yunting Jian,
- Junye Wang,
- Chengmei Huang,
- Shuang Mo,
- Yue Li,
- Fengtian Li,
- Chao Zhang,
- Dongsheng Zhang,
- Huizhong Zhang,
- Huilin Huang,
- Xin Chen,
- Y. Alan Wang,
- Chuyong Lin,
- Guozhen Liu,
- Libing Song,
- Wenting Liao
Affiliations
- Dongni Shi
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Xianqiu Wu
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Yunting Jian
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Junye Wang
- Department of Thoracic Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Chengmei Huang
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Shuang Mo
- Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University
- Yue Li
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Fengtian Li
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Chao Zhang
- Department of Pathology, Sun Yat-sen University Cancer Center
- Dongsheng Zhang
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Huizhong Zhang
- Department of Pathology, Sun Yat-sen University Cancer Center
- Huilin Huang
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Xin Chen
- Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Institute of Oncology, Tumor Hospital, Guangzhou Medical University
- Y. Alan Wang
- Brown Center for Immunotherapy, Department of Medicine, Indiana University School of Medicine, Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Chuyong Lin
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Guozhen Liu
- School of Life and Health Sciences, The Chinese University of Hong Kong
- Libing Song
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Wenting Liao
- Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33285-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
IDO1-mediated tryptophan metabolism plays an important role in creating an immunosuppressive tumour microenvironment. Here, the authors show that deubiquitinase USP14 regulates immune suppression by inducing IDO1 stabilization and suggest USP14 as a potential therapeutic target to improve immunotherapy in colorectal cancer.
