Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity

Abstract

This work describes the fabrication of a carbazole derivative 1 namely (E)-5-(diethylamino)-2-((9-ethyl-9H-carbazol-3-yl)imino)methyl)phenol(1) based colorimetric probe for the selective detection of copper (II) ions. The as-prepared carbazole derivative was characterized using various spectral techniques including UV–visible absorption, Emission, FT-IR, 1H NMR, 13C NMR and mass spectra. The colorimetric chemosensing potential of the synthesized carbazole derivative 1 to detect Cu2+ ions in a solution of different cations at different emission wavelengths based on photo-induced electron transfer (PET) mechanism was undertaken. In addition, the probe 1 showed significant DPPH scavenging activity. Antimicrobial and anti-inflammatory activities of the carbazole derivative 1 were also assessed. The selectivity of probe 1 towards Cu2+ ions could be exploited to reduce copper induced toxicity.

Keywords

• Carbazole based metal sensor
• Naked eye detection of copper ions
• Photo electron transfer
• Oxidative stress reduction
• Inflammation healing
• Microbes inhibition