<i>Aspergillus fumigatus</i> Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma

Abstract

We review three recent findings that have fundamentally altered our understanding of causative mechanisms underlying fungal-related asthma. These mechanisms may be partially independent of host inflammatory processes but are strongly dependent upon the actions of Alp1 on lung structural cells. They entail (i) bronchial epithelial sensing of Alp1; (ii) Alp1-induced airway smooth muscle (ASM) contraction; (iii) Alp1-induced airflow obstruction. Collectively, these mechanisms point to Alp1 as a new target for intervention in fungal asthma.

Keywords

• <i>Aspergillus fumigatus</i>
• airway smooth muscle
• contraction
• AHR