Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats

Abstract

Introduction: camphorated p-chlorophenol is a chlorophenolic derivative commonly used as an intra-oral medication in endodontics. Scientific reports on its effects in arterial vascular smooth muscle and local blood flow regulation are scarce. Objective: to determine the effect of camphorated p-chlorophenol on the contractile dynamics of arterial vascular smooth muscle. Method: an experimental and preclinical research was conducted with the use of 14 aortic rings of Wistar rats. The rings were placed in an organ bath and preactivated with noradrenaline, and the tension developed by the vascular smooth muscle at different time intervals was recorded after induction of camphorated p-chlorophenol. Results: most of the vascular smooth muscle (51.4%) relaxed with the use of camphorated p-chlorophenol. The greatest decrease in vascular tone occurred between the third and fifth minute after use the drug. Wilcoxon rank tests showed significant differences between tension observed at baseline and those recorded at the different time intervals studied. Conclusions: camphorated p-chlorophenol, induces in vitro, relax the arterial smooth muscle through a pharmacomechanical excitation-contraction link, which increases according to the time.

Keywords

• músculo liso vascular
• tensión muscular
• vasodilatación
• baño de órganos
• medicación intracanal
• p-clorofenol alcanforado