Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

Pichet Praveschotinunt; Anna M. Duraj-Thatte; Ilia Gelfat; Franziska Bahl; David B. Chou; Neel S. Joshi

doi:10.1038/s41467-019-13336-6

Nature Communications (Dec 2019)

Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

Pichet Praveschotinunt,
Anna M. Duraj-Thatte,
Ilia Gelfat,
Franziska Bahl,
David B. Chou,
Neel S. Joshi

Affiliations

Pichet Praveschotinunt: Wyss Institute for Biologically Inspired Engineering, Harvard University
Anna M. Duraj-Thatte: Wyss Institute for Biologically Inspired Engineering, Harvard University
Ilia Gelfat: Wyss Institute for Biologically Inspired Engineering, Harvard University
Franziska Bahl: Wyss Institute for Biologically Inspired Engineering, Harvard University
David B. Chou: Wyss Institute for Biologically Inspired Engineering, Harvard University
Neel S. Joshi: Wyss Institute for Biologically Inspired Engineering, Harvard University

DOI: https://doi.org/10.1038/s41467-019-13336-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Anti-inflammatory treatments for gastrointestinal diseases can often have detrimental side effects. Here the authors engineer E. coli Nissle 1917 to create a fibrous matrix that has a protective effect in DSS-induced colitis mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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