Опухоли женской репродуктивной системы (Jul 2014)

Current molecular genetic markers of breast cancer

  • N. V. Apanovich,
  • V. P. Shubin,
  • A. A. Korotayeva,
  • A. S. Bavykin,
  • E. A. Kim,
  • A. D. Zakiryakhodzhayev,
  • V. P. Letyagin,
  • I. V. Vysotskaya,
  • A. V. Karpukhin

DOI
https://doi.org/10.17650/1994-4098-2011-0-1-19-28
Journal volume & issue
Vol. 0, no. 1
pp. 19 – 28

Abstract

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The paper concerns the molecular and genetic markers of breast cancer (BC). For practice use it is expedient to limit a BC expression analysis panel with the VEGFR 1, VEGFR 2, VEGF 121, PDGFR, mTOR, Her-2/neu, Ki-67, BRCA 1, ESR 1, Ostp, BIRC 2 and BIRC 5 genes to accelerate the test and reduce its cost and to simplify interpretation by physicians. These 12 genes carry basic information that is required to choose and predict a chemotherapy response and that serves as its prognostic markers, by indicating the potential therapeutic targets.

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