Опухоли женской репродуктивной системы (Jul 2014)
Current molecular genetic markers of breast cancer
Abstract
The paper concerns the molecular and genetic markers of breast cancer (BC). For practice use it is expedient to limit a BC expression analysis panel with the VEGFR 1, VEGFR 2, VEGF 121, PDGFR, mTOR, Her-2/neu, Ki-67, BRCA 1, ESR 1, Ostp, BIRC 2 and BIRC 5 genes to accelerate the test and reduce its cost and to simplify interpretation by physicians. These 12 genes carry basic information that is required to choose and predict a chemotherapy response and that serves as its prognostic markers, by indicating the potential therapeutic targets.
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