Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy

• Jiajia Zhang,
• Julie R Brahmer,
• Patrick M Forde,
• Tanguy Seiwert,
• Valsamo Anagnostou,
• Samuel Rosner,
• Victor E Velculescu,
• James R White,
• Joshua E Reuss,
• Gavin Pereira,
• Vincent Lam,
• Christine Hann,
• Michael Hwang,
• Kristen Marrone,
• Kellie N Smith,
• Joseph C Murray,
• Jamie E Chaft,
• Lavanya Sivapalan,
• Jenna Vanliere Canzoniero,
• Guangfan Zhang,
• Zineb Belcaid,
• Christopher Cherry,
• Archana Balan,
• Alexandria Curry,
• Noushin Niknafs,
• Qing Kay Li,
• Benjamin P Levy

Affiliations

Jiajia Zhang

Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins, Baltimore, Maryland, USA

Julie R Brahmer

Department of Oncology and the Thoracic Oncology, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, USA

Patrick M Forde

Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA

Tanguy Seiwert

Aff247 grid.170205.10000000419367822University of Chicago, Chicago Chicago IL USA

Valsamo Anagnostou

Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA

Samuel Rosner

Department of Oncology, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA

Victor E Velculescu

Aff1 grid.21107.350000000121719311Department of OncologyJohns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center Baltimore MD USA

James R White

Resphera Biosciences, Baltimore, Maryland, USA

Joshua E Reuss

1 Oncology, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA

Gavin Pereira

8 School of Public Health, Curtin University, Perth, Western Australia, Australia

Vincent Lam

1MD Anderson Cancer Center, Houston, TX, USA

Christine Hann

Oncology, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA

Michael Hwang

1Johns Hopkins University School of Medicine, Baltimore, MD, USA

Kristen Marrone

Oncology, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA

Kellie N Smith

The Bloomberg–Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland, USA

Joseph C Murray

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, Maryland, USA

Jamie E Chaft

Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Lavanya Sivapalan

Centre for Cancer Biomarker and Biotherapeutics, Barts Cancer Institute, London, UK

Jenna Vanliere Canzoniero

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Guangfan Zhang

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Zineb Belcaid

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Christopher Cherry

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Archana Balan

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Alexandria Curry

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Noushin Niknafs

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Qing Kay Li

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Benjamin P Levy

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA