Association between intrahepatic cholestasis of pregnancy and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis

Abstract

Objective To investigate the association between intrahepatic cholestasis of pregnancy (ICP) and the risk of gestational diabetes mellitus (GDM) and preeclampsia via meta-analysis. Methods Pooled odds ratio (OR) and confidence interval (CI) of GDM and preeclampsia for women with ICP were calculated using the fixed- or random-effects model. Results Women with ICP were more likely to have GDM (pooled OR = 2.19, 95% CI: 1.58, 3.03, I2 = 88.25%) and preeclampsia (pooled OR = 2.58, 95% CI: 2.37, 2.81, I2 = 0%) than women without ICP. Conclusion The present study supports the concept that ICP is associated with the risk of GDM and preeclampsia.

Keywords

• intrahepatic cholestasis of pregnancy
• gestational diabetes
• preeclampsia
• meta-analysis