Risk Factors of Dyspepsia Development during Anti-tuberculosis Chemotherapy in Children

Abstract

The objective: to identify factors influencing the development of dyspepsia in children during treatment with anti-tuberculosis drugs.Results: out of 243 children during chemotherapy, 22.6% developed dyspepsia as an adverse reaction. Risk factors significantly associated with the development of dyspepsia were as follows: formula feeding at birth, comorbidities of the gastrointestinal tract, decreased total protein and elevated leukocyte counts by the admission to hospital, tuberculosis treatment as per regimens IV or V, and inclusion of protionamide or para-aminosalicylic acid to the regimen. Based on the method of logistic regression, the following has been developed: the method to predict the risk of developing dyspepsia during anti-tuberculosis chemotherapy in children with a sensitivity of 93%; the PC software to calculate such a risk.

Keywords

• туберкулез легких
• нежелательные реакции
• противотуберкулезная терапия у детей
• синдром диспепсии