Nature Communications (Mar 2023)
Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage
- Annarita Nappi,
- Caterina Miro,
- Antonio Pezone,
- Alfonso Tramontano,
- Emery Di Cicco,
- Serena Sagliocchi,
- Annunziata Gaetana Cicatiello,
- Melania Murolo,
- Sepehr Torabinejad,
- Elena Abbotto,
- Giuseppina Caiazzo,
- Maddalena Raia,
- Mariano Stornaiuolo,
- Dario Antonini,
- Gabriella Fabbrocini,
- Domenico Salvatore,
- Vittorio Enrico Avvedimento,
- Monica Dentice
Affiliations
- Annarita Nappi
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Caterina Miro
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Antonio Pezone
- Department of Biology, University of Naples “Federico II”
- Alfonso Tramontano
- Department of Precision Medicine, University of Campania “L. Vanvitelli”
- Emery Di Cicco
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Serena Sagliocchi
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Annunziata Gaetana Cicatiello
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Melania Murolo
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Sepehr Torabinejad
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Elena Abbotto
- Department of Experimental Medicine, University of Genoa
- Giuseppina Caiazzo
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Maddalena Raia
- CEINGE, Biotecnologie Avanzate S.c.a.r.l.
- Mariano Stornaiuolo
- Department of Pharmacy, University of Naples “Federico II”
- Dario Antonini
- Department of Biology, University of Naples “Federico II”
- Gabriella Fabbrocini
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Domenico Salvatore
- CEINGE, Biotecnologie Avanzate S.c.a.r.l.
- Vittorio Enrico Avvedimento
- Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”
- Monica Dentice
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- DOI
- https://doi.org/10.1038/s41467-023-36755-y
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
Thyroid hormones have an important role in fostering tumour progression, however their upstream regulators are less clear. Here, the authors identify the thyroid hormone activating enzyme type 2 deiodinase as a p53 target gene and demonstrate its contribution to tumour progression in p53 mutant squamous cell carcinoma.
