Exploring the role of stromal osmoregulation in cancer and disease using executable modelling

David Shorthouse; Angela Riedel; Emma Kerr; Luisa Pedro; Dóra Bihary; Shamith Samarajiwa; Carla P. Martins; Jacqueline Shields; Benjamin A. Hall

doi:10.1038/s41467-018-05414-y

Nature Communications (Aug 2018)

Exploring the role of stromal osmoregulation in cancer and disease using executable modelling

David Shorthouse,
Angela Riedel,
Emma Kerr,
Luisa Pedro,
Dóra Bihary,
Shamith Samarajiwa,
Carla P. Martins,
Jacqueline Shields,
Benjamin A. Hall

Affiliations

David Shorthouse: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Angela Riedel: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Emma Kerr: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Luisa Pedro: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Dóra Bihary: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Shamith Samarajiwa: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Carla P. Martins: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Jacqueline Shields: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Benjamin A. Hall: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre

DOI: https://doi.org/10.1038/s41467-018-05414-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Aberrant ion transporter expression disrupts osmoregulation in many cancers. Here, the authors introduce an executable model of osmotic regulation and membrane transport, illuminating the mechanistic basis of multiple cellular cancer phenotypes and suggesting therapeutic avenues.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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