Hypothyroidism and the increased risk of preeclampsia – interpretative factors?

Abstract

Objective To evaluate the causes behind the association between hypothyroidism and the risk of preeclampsia. Methods Checking of individual hospital and birth records from 149 levothyroxine users among 2,508 women in the preeclampsia case–control study (2002-2016). Results There were significant association between levothyroxine medication and preeclampsia (OR 1.48, 95th CI 1.06–2.07; p ≤ 0.022). The presence of comorbid diseases was associated with a significantly higher risk for the development of preeclampsia in women using levothyroxine. Conclusion Levothyroxine use during pregnancy was associated with 1.5-times higher risk for preeclampsia, but it is also linked to the other comorbid risk factors.

Keywords

• pregnancy
• hypothyroidism
• levothyroxine
• preeclampsia
• diabetes
• hypertension