Frontiers in Plant Science (Nov 2022)
Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7B
- Yan Chen,
- Yan Chen,
- Yan Chen,
- Huan Wang,
- Xin Ke,
- Xin Ke,
- Xin Ke,
- Zihuan Sang,
- Zihuan Sang,
- Zihuan Sang,
- Min Kuang,
- Min Kuang,
- Weiwei Peng,
- Weiwei Peng,
- Weiwei Peng,
- Jianbing Tan,
- Jianbing Tan,
- Yuting Zheng,
- Yuting Zheng,
- Zhenxing Zou,
- Zhenxing Zou,
- Haibo Tan,
- Haibo Tan,
- Haibo Tan
Affiliations
- Yan Chen
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Yan Chen
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Yan Chen
- Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
- Huan Wang
- Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
- Xin Ke
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Xin Ke
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Xin Ke
- Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
- Zihuan Sang
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Zihuan Sang
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Zihuan Sang
- Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
- Min Kuang
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Min Kuang
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Weiwei Peng
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Weiwei Peng
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Weiwei Peng
- Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
- Jianbing Tan
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Jianbing Tan
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Yuting Zheng
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Yuting Zheng
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Zhenxing Zou
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Zhenxing Zou
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Haibo Tan
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Haibo Tan
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Haibo Tan
- Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
- DOI
- https://doi.org/10.3389/fpls.2022.1049015
- Journal volume & issue
-
Vol. 13
Abstract
Two previously undescribed lactones, phomolides A and B (1 and 2), and three new sesquiterpenoids, phomenes A–C (3–5), together with one known compound, colletotricholide A (6), were isolated from the endophytic fungus Phomopsis sp. SZSJ-7B. Their chemical structures, including the absolute configurations, were comprehensively established by extensive analyses of NMR, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism powered by theoretical calculations, and X-ray diffractions. Moreover, the cytotoxic and antibacterial activities of compounds 1–6 were also evaluated, and the results demonstrated that compound 2 showed significant antibacterial effects towards methicillin-resistant Staphylococcus aureus and S. aureus strains with minimum inhibitory concentration as low as 6.25 μg/ml, which was comparable to that of the clinical drug vancomycin. Moreover, all compounds showed no cytotoxic activity.
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