Diabetes, Metabolic Syndrome and Obesity (Aug 2024)
Current Updates on the Understanding of the Role of DNA Methylation on Obesity
Abstract
Mohammad Parezal Lastialno,1 Muhammad Hasan Bashari,2 Eko Fuji Ariyanto2,3 1Program of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, 40161, Indonesia; 2Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, 45363, Indonesia; 3Study Center for Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, 40161, IndonesiaCorrespondence: Eko Fuji Ariyanto, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km.21, Sumedang, West Java, 45363, Indonesia, Email [email protected]: Obesity is a condition in which there is an accumulation of excess body fat leading to a weight far above the normal range that poses significant health risks. According to WHO, 8 billion people in the world were obese in 2022. Consequently, obesity has become a pandemic with negative impacts on both global health and economies. Obesity is influenced by various factors including environmental influences, lifestyle choices, gut microbiota, genetic factors, and epigenetic mechanisms such as DNA methylation. DNA methylation can affect an individual’s phenotype and condition without altering their DNA sequence. It is the most extensively studied epigenetic alteration and it plays an important part in controlling gene activity associated with obesity. Numerous studies have indicated that DNA methylation is implicated in obesity, thus this review aims to elaborate the roles of DNA methylation to inform the development of preventive measures for obesity.Keywords: DNA methylation, epigenetics, obesity, prevention
