Radical azidation as a means of constructing C(sp3)-N3 bonds

Liang Ge; Mong-Feng Chiou; Yajun Li; Hongli Bao

Green Synthesis and Catalysis (Nov 2020)

Radical azidation as a means of constructing C(sp3)-N3 bonds

Liang Ge,
Mong-Feng Chiou,
Yajun Li,
Hongli Bao

Affiliations

Liang Ge: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; University of Chinese Academy of Sciences, Beijing 100049, China
Mong-Feng Chiou: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
Yajun Li: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
Hongli Bao: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding author. Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.

Journal volume & issue: Vol. 1, no. 2
pp. 86 – 120

Abstract

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The azido group is found in large numbers of natural products, drugs, biochemicals and materials and to date, many elegant and useful methods for the synthesis of organic azides and their transformations have been documented. In this review, we provide a summary of the state of the art of radical azidation for the construction of C(sp3)-N3 bonds. There is a specific emphasis on the synthetic reactions involving C(sp3)-H azidation, decarboxylative azidation and difunctionalized azidation of olefins. This review will be useful to those working in this field and hopefully could inspire further development of radical azidation reactions.

Published in Green Synthesis and Catalysis

ISSN: 2666-5549 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.keaipublishing.com/en/journals/green-synthesis-and-catalysis/

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