Mediators of Inflammation (Jan 2013)

Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction

  • Alessandra Puddu,
  • Roberta Sanguineti,
  • François Mach,
  • Franco Dallegri,
  • Giorgio Luciano Viviani,
  • Fabrizio Montecucco

DOI
https://doi.org/10.1155/2013/750540
Journal volume & issue
Vol. 2013

Abstract

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The primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia and, ultimately, diabetes mellitus. Therefore, strategies targeting the maintenance of the normal function and protecting pancreatic beta-cells from injury or death might be crucial in the treatment of diabetes. This narrative review will update evidence from the recently identified molecular regulators preserving beta-cell mass and function recovery in order to suggest potential therapeutic targets against diabetes. This review will also highlight the relevance for novel molecular pathways potentially improving beta-cell dysfunction.