Nature Communications (Aug 2016)

Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling

  • Paulo Navarro-Costa,
  • Alicia McCarthy,
  • Pedro Prudêncio,
  • Christina Greer,
  • Leonardo G. Guilgur,
  • Jörg D. Becker,
  • Julie Secombe,
  • Prashanth Rangan,
  • Rui G. Martinho

DOI
https://doi.org/10.1038/ncomms12331
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

Read online

Meiotically arrested oocytes retain transcriptional ability despite chromosome condensation. Here, the authors show that Drosophilaoocytes regulate meiotic transcription and chromatin remodelling through the programming, in early oogenesis, of an extremely diversified epigenome.