Communications Biology (May 2021)

Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

  • Fiona C. Simpson,
  • Christopher D. McTiernan,
  • Mohammad Mirazul Islam,
  • Oleksiy Buznyk,
  • Philip N. Lewis,
  • Keith M. Meek,
  • Michel Haagdorens,
  • Cindy Audiger,
  • Sylvie Lesage,
  • François-Xavier Gueriot,
  • Isabelle Brunette,
  • Marie-Claude Robert,
  • David Olsen,
  • Laura Koivusalo,
  • Aneta Liszka,
  • Per Fagerholm,
  • Miguel Gonzalez-Andrades,
  • May Griffith

DOI
https://doi.org/10.1038/s42003-021-02108-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Simpson, McTiernan et al. develop fully synthetic corneal implants. The resulting CLP-PEG-MPC implants show reduced corneal swelling, haze, and neovascularization compared to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. This study suggests the superiority of CLP-PEG-MPC implants over the CLP-PEG only implants.