GENETIC AND MOLECULAR BASIS OF ASYMPTOMATIC BACTERIURIA IN CHILDREN: WHAT’S NEW?

Abstract

Due to improvement of genetic and molecular methods of study of both micro-organisms and individual human cell structures, the interest of scientists in the finest mechanisms of interaction between macro- and microorganisms has sprung up in recent years. The study of the microbiota and the diversity of microorganisms in all parts of the human body gave rise to a new understanding of the development of many diseases and, accordingly, to the possibility of creating new therapeutic approaches. The microbiota of the bladder is no exception either. The mechanisms of the formation of asymptomatic bacteriuria (AB) and urinary tract infection (UTI) are of interest to many scientists. The presented article is devoted to the review of recent studies focused on the genetic, immune and molecular mechanisms of interaction between macro- and microorganisms in the development of UTI.

Keywords

• escherichia coli 83972
• lactobacillus species
• toll-like receptor
• bacterial interference
• asymptomatic bacteriuria
• children
• urinary tract infection
• acute cystitis
• pyelonephritis
• rna-dependent polymerase ii
• virulence factors