GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons

Xinglong Gu; Xia Mao; Marc P. Lussier; Mary Anne Hutchison; Liang Zhou; F. Kent Hamra; Katherine W. Roche; Wei Lu

doi:10.1038/ncomms10873

Nature Communications (Mar 2016)

GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons

Xinglong Gu,
Xia Mao,
Marc P. Lussier,
Mary Anne Hutchison,
Liang Zhou,
F. Kent Hamra,
Katherine W. Roche,
Wei Lu

Affiliations

Xinglong Gu: Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, 3C1000, Bethesda, Maryland 20892, USA
Xia Mao: Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, 3C1000, Bethesda, Maryland 20892, USA
Marc P. Lussier: Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, 2C903, Bethesda, Maryland 20892, USA
Mary Anne Hutchison: Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, 3C1000, Bethesda, Maryland 20892, USA
Liang Zhou: Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, 3C1000, Bethesda, Maryland 20892, USA
F. Kent Hamra: Department of Pharmacology, Cecil H. & Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center in Dallas
Katherine W. Roche: Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, 2C903, Bethesda, Maryland 20892, USA
Wei Lu: Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, 3C1000, Bethesda, Maryland 20892, USA

DOI: https://doi.org/10.1038/ncomms10873
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 18

Abstract

Read online

The molecular mechanism controlling the trafficking and function of AMPARs at synapses are not fully understood. Here the authors show that GSG1L, a membrane protein, negatively regulates AMPAR-mediated synaptic transmission and represents a new class of AMPAR auxiliary subunit.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal