Nature Communications (Aug 2020)
Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
- Lianmin Chen,
- Valerie Collij,
- Martin Jaeger,
- Inge C. L. van den Munckhof,
- Arnau Vich Vila,
- Alexander Kurilshikov,
- Ranko Gacesa,
- Trishla Sinha,
- Marije Oosting,
- Leo A. B. Joosten,
- Joost H. W. Rutten,
- Niels P. Riksen,
- Ramnik J. Xavier,
- Folkert Kuipers,
- Cisca Wijmenga,
- Alexandra Zhernakova,
- Mihai G. Netea,
- Rinse K. Weersma,
- Jingyuan Fu
Affiliations
- Lianmin Chen
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Valerie Collij
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Martin Jaeger
- Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Inge C. L. van den Munckhof
- Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Arnau Vich Vila
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Alexander Kurilshikov
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Ranko Gacesa
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Trishla Sinha
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Marije Oosting
- Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Leo A. B. Joosten
- Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Joost H. W. Rutten
- Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Niels P. Riksen
- Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Ramnik J. Xavier
- Center for Computational and Integrative Biology, Massachusetts General Hospital
- Folkert Kuipers
- Department of Pediatrics, University of Groningen, University Medical Center Groningen
- Cisca Wijmenga
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Alexandra Zhernakova
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Mihai G. Netea
- Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Rinse K. Weersma
- Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen
- Jingyuan Fu
- Department of Genetics, University of Groningen, University Medical Center Groningen
- DOI
- https://doi.org/10.1038/s41467-020-17840-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Gut microbiome alterations have been linked to inflammatory bowel disease (IBD) and obesity. Here, the authors characterize the metagenomes of four large human cohorts and perform co-abundance network analysis showing that dysbiosis in disease is marked by the altered co-abundance relationships, suggesting that pathway coabundance networks are more heterogeneous than species network.
