Expanding transplant options to patients over 50 years. Improved outcome after reduced intensity conditioning mismatched-unrelated donor transplantation for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the EBMT
Bipin N. Savani,
Myriam Labopin,
Nicolaus Kröger,
Jürgen Finke,
Gerhard Ehninger,
Dietger Niederwieser,
Rainer Schwerdtfeger,
Donald Bunjes,
Bertram Glass,
Gerard Socié,
Per Ljungman,
Charles Craddock,
Frédéric Baron,
Fabio Ciceri,
Norbert Claude Gorin,
Jordi Esteve,
Christoph Schmid,
Sebastian Giebel,
Mohamad Mohty,
Arnon Nagler
Affiliations
Bipin N. Savani
Vanderbilt University Medical Center, Nashville, TN, USA;Acute Leukemia Working Party, EBMT Paris study office / CEREST-TC, France
Myriam Labopin
Acute Leukemia Working Party, EBMT Paris study office / CEREST-TC, France;Department of Haematology, Saint Antoine Hospital, Paris, France;INSERM UMR 938, Paris, France;Université Pierre et Marie Curie, Paris, France
Nicolaus Kröger
University Hospital Eppendorf, Department of Stem cell Transplantation, Hamburg, Germany
Jürgen Finke
University of Freiburg, Department of Medicine –Hematology, Oncology, Germany
Gerhard Ehninger
Universitaetsklinikum Dresden, MedizinischeKlinik und Poliklinik I, Germany
Dietger Niederwieser
University Hospital Leipzig, Div. Hematology, Oncology and Hemostasiology, Germany
Klinik fuer Innere Medzin III - Universitätsklinikum Ulm, Germany
Bertram Glass
Asklepios Klinik St. Georg - Department of Haematology, Hamburg, Germany
Gerard Socié
Hopital St. Louis - Dept.of Hematology, Paris, France
Per Ljungman
Karolinska University Hospital, Department of Hematology, Stockholm, Sweden
Charles Craddock
Center for Clinical Hematology, Queen Elizabeth Hospital, Birmingham, UK
Frédéric Baron
Department of Medicine, Division of Hematology, University of Liège, Belgium
Fabio Ciceri
Department of Hematology, Ospedale San Raffaele, Università degli Studi, Milan, Italy
Norbert Claude Gorin
Faculté de Médicine Saint-Antoine, Paris, France
Jordi Esteve
Dept. of Hematology, Hospital Clinic, Barcelona, Spain
Christoph Schmid
Klinikum Augsburg, Dept. of Hematology and Oncology, University of Munich, Augsburg, Germany
Sebastian Giebel
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland
Mohamad Mohty
Acute Leukemia Working Party, EBMT Paris study office / CEREST-TC, France;Department of Haematology, Saint Antoine Hospital, Paris, France;INSERM UMR 938, Paris, France;Université Pierre et Marie Curie, Paris, France
Arnon Nagler
Acute Leukemia Working Party, EBMT Paris study office / CEREST-TC, France;Hematology Division, Chaim Sheba Medical Center, Tel Hashomer, Israel
The outcome of patients undergoing HLA-matched unrelated donor allogeneic hematopoietic cell transplantation following reduced-intensity conditioning or myeloablative regimens is reported to be equivalent; however, it is not known if the intensity of the conditioning impacts outcomes after mismatched unrelated donor transplantation for acute myeloid leukemia. Eight hundred and eighty three patients receiving reduced-intensity conditioning were compared with 1041 myeloablative conditioning regimen recipients in the setting of mismatched unrelated donor transplantation. The donor graft was HLA-matched at 9/10 in 872 (83.8%) and at 8/10 in 169 (16.2%) myeloablative conditioning recipients, while in the reduced-intensity conditioning cohort, 754 (85.4%) and 129 (14.6%) were matched at 9/10 and 8/10 loci, respectively. Myeloablative conditioning regimen recipients were younger, 70% being
