Microglial APOE4: more is less and less is more

Abstract

Abstract Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimer’s disease (AD). Yet, the cell-specific effects of APOE on microglia function have remained unclear. Fortunately, two comprehensive new studies published in the latest issue of Nature Immunology have employed complementary gain-of-function and loss-of-function approaches to provide critical new insight into the impact of microglial APOE on AD pathogenesis.

Keywords

• Apolipoprotein E
• Microglia
• APOE4
• APOE3
• Alzheimer’s disease
• Lgals3