Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum

Jie Lin; Shubin Niu; Zhengfeng Ding; Renlei Wang; Qun Dai; Wei Wei; Rongrong Luo; Ling Liu

doi:10.3390/molecules22071168

Molecules (Jul 2017)

Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum

Jie Lin,
Shubin Niu,
Zhengfeng Ding,
Renlei Wang,
Qun Dai,
Wei Wei,
Rongrong Luo,
Ling Liu

Affiliations

Jie Lin: Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry,Jiangsu Second Normal University, Nanjing 210003, China
Shubin Niu: School of Biomedicine, Beijing City University, Beijing 100083, China
Zhengfeng Ding: Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry,Jiangsu Second Normal University, Nanjing 210003, China
Renlei Wang: Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry,Jiangsu Second Normal University, Nanjing 210003, China
Qun Dai: Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry,Jiangsu Second Normal University, Nanjing 210003, China
Wei Wei: Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry,Jiangsu Second Normal University, Nanjing 210003, China
Rongrong Luo: Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry,Jiangsu Second Normal University, Nanjing 210003, China
Ling Liu: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

DOI: https://doi.org/10.3390/molecules22071168
Journal volume & issue: Vol. 22, no. 7
p. 1168

Abstract

Read online

Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh2(OCOCF3)4] complexes. Compounds 1, 4, 5, 7, and 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords