CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH CHRONIC OBSTRUCIVE PULMONARY DISEASE IN COMBINATION WITH THE HYPERTONIC DISEASE: NEW DIRECTIONS OF PATHOGENETIC THERAPY

Abstract

The purpose of the study was to study of effects of sulodexide on clinical and functional parameters in patients with chronic obstructive pulmonary disease (COPD) in combination with hypertension. 40 COPD patients were examined. Patients were divided into two groups of 20 people. One group received only basic COPD therapy and antihypertensive treatment, the other group - basic and antihypertensive therapy in combination with sulodexide. After a year of observation the assessment of the clinical course of the disease, and ventilatory lung function, cardiopulmonary hemodynamics, endothelium-dependent vasomotor function was done.In patients, additionally treated with sulodexide, the following parameters were marked: stabilization of blood pressure parameters, reduction of dizziness and headaches, increase of tolerance to physical load, reducing the number of exacerbations, improvement in spirometry, lung diffusion capacity, improvement of pulmonary hemodynamics parameters and improvement of endothelium-dependentvasodilation. Thus, the positive effect of sulodexide on clinical and functional parameters indicates the feasibility of further study of the use of angioprotectors in complex pathogenetic therapy of COPD.

Keywords

• copd
• arterial hypertension
• endothelial function
• pulmonary and cardiac hemodynamics
• sulodexide