PLoS ONE (Jan 2015)

Intravoxel Incoherent Motion Diffusion Weighted MR Imaging at 3.0 T: Assessment of Steatohepatitis and Fibrosis Compared with Liver Biopsy in Type 2 Diabetic Patients.

  • Daniella Braz Parente,
  • Fernando Fernandes Paiva,
  • Jaime Araújo Oliveira Neto,
  • Lilian Machado-Silva,
  • Fatima Aparecida Ferreira Figueiredo,
  • Valeria Lanzoni,
  • Carlos Frederico Ferreira Campos,
  • Pedro Emmanuel Alvarenga Americano do Brasil,
  • Marilia de Brito Gomes,
  • Renata de Mello Perez,
  • Rosana Souza Rodrigues

DOI
https://doi.org/10.1371/journal.pone.0125653
Journal volume & issue
Vol. 10, no. 5
p. e0125653

Abstract

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To evaluate the capability of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) to assess steatohepatitis and fibrosis determined by histopathology in type 2 diabetic patients.Fifty-nine type 2 diabetic patients (49 women, 10 men; mean age, 54 ± 9 years) were submitted to liver biopsy for the evaluation of non-alcoholic fatty liver disease (NAFLD) and underwent DWI on a 3.0T MR system using 10 b values. Institutional approval and patient consent were obtained. Pure molecular-based (D), perfusion-related (D*), and vascular fraction (f) were calculated using a double exponential model and least squares curve fitting. D, D*, and f were compared between patients with and without steatohepatitis and between patients with and without fibrosis. The variables were compared by using the Ranksum test and Student t-test.Steatohepatitis was observed in 22 patients and fibrosis in 16 patients. A lower D median (0.70 s/mm2 vs. 0.83 s/mm2, p<0.05) and a lower D* median (34.39 s/mm2 vs. 45.23 s/mm2, p<0.05) were observed among those with steatohepatitis. A lower D median (0.70 s/mm2 vs. 0.82 s/mm2, p<0.05) and a lower D* median (35.01 s/mm2 vs. 44.76 s/mm2, p=0.05) were also observed among those with fibrosis.IVIM-DWI has the potential to aid in the characterization of steatohepatitis and fibrosis.