Nature Communications (Jan 2023)
Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1
- Prameladevi Chinnasamy,
- Isabel Casimiro,
- Dario F. Riascos-Bernal,
- Shreeganesh Venkatesh,
- Dippal Parikh,
- Alishba Maira,
- Aparna Srinivasan,
- Wei Zheng,
- Elena Tarabra,
- Haihong Zong,
- Smitha Jayakumar,
- Venkatesh Jeganathan,
- Kith Pradan,
- Jose O. Aleman,
- Rajat Singh,
- Sayan Nandi,
- Jeffrey E. Pessin,
- Nicholas E. S. Sibinga
Affiliations
- Prameladevi Chinnasamy
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- Isabel Casimiro
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- Dario F. Riascos-Bernal
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- Shreeganesh Venkatesh
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- Dippal Parikh
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- Alishba Maira
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- Aparna Srinivasan
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- Wei Zheng
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Elena Tarabra
- Department of Molecular Pharmacology, Albert Einstein College of Medicine
- Haihong Zong
- Department of Medicine (Endocrinology, Albert Einstein College of Medicine)
- Smitha Jayakumar
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- Venkatesh Jeganathan
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- Kith Pradan
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Jose O. Aleman
- Department of Medicine (Endocrinology), New York University Langone Health
- Rajat Singh
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Sayan Nandi
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Jeffrey E. Pessin
- Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
- Nicholas E. S. Sibinga
- Department of Medicine (Cardiology), Albert Einstein College of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-35683-7
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Macrophages have been reported to regulate thermogenic, sympathetic neuron-mediated norepinephrine signaling in adipose tissues. Here the authors report that male mice lacking the allograft inflammatory factor-1 protein are resistant to diet-induced obesity, in association with higher adipose norepinephrine levels and lower expression of the norepinephrine catabolic enzyme monoamine oxidase A.
