Combined Nabpaclitaxel pressurized intraPeritoneal aerosol chemotherapy with systemic Nabpaclitaxel-Gemcitabine chemotherapy for pancreatic cancer peritoneal metastases: protocol of single-arm, open-label, phase II trial (Nab-PIPAC trial)

Di Giorgio Andrea; Ferracci Federica; Bagalà Cinzia; Carbone Carmine; Salvatore Lisa; Strippoli Antonia; Attalla El Halabieh Miriam; Abatini Carlo; Alfieri Sergio; Pacelli Fabio; Tortora Giampaolo

doi:10.1515/pp-2024-0010

Pleura and Peritoneum (Nov 2024)

Combined Nabpaclitaxel pressurized intraPeritoneal aerosol chemotherapy with systemic Nabpaclitaxel-Gemcitabine chemotherapy for pancreatic cancer peritoneal metastases: protocol of single-arm, open-label, phase II trial (Nab-PIPAC trial)

Di Giorgio Andrea,
Ferracci Federica,
Bagalà Cinzia,
Carbone Carmine,
Salvatore Lisa,
Strippoli Antonia,
Attalla El Halabieh Miriam,
Abatini Carlo,
Alfieri Sergio,
Pacelli Fabio,
Tortora Giampaolo

Affiliations

Di Giorgio Andrea: Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Ferracci Federica: Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Bagalà Cinzia: Comprehensive Cancer Center, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy
Carbone Carmine: Department of Medical and Surgical Science, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Salvatore Lisa: Comprehensive Cancer Center, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy
Strippoli Antonia: Comprehensive Cancer Center, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy
Attalla El Halabieh Miriam: Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Abatini Carlo: Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Alfieri Sergio: Surgical Unit of Digestive Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Pacelli Fabio: Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Tortora Giampaolo: Comprehensive Cancer Center, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy

DOI: https://doi.org/10.1515/pp-2024-0010
Journal volume & issue: Vol. 9, no. 3
pp. 121 – 129

Abstract

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Current therapies show limited efficacy against peritoneal metastases (PM) from pancreatic cancer. Pressurized intra-peritoneal aerosol chemotherapy (PIPAC) has emerged as a novel intraperitoneal drug delivery method. Recently, a dose-escalation study identified the safe dose of Nabpaclitaxel for PIPAC administration, an ideal intraperitoneal chemotherapy agent against pancreatic cancer. Combining systemic NabPaclitaxel-Gemcitabine with NabPaclitaxel-PIPAC may enhance disease control in pancreatic cancer patients with PM.

Published in Pleura and Peritoneum

ISSN: 2364-768X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine
Website: https://www.degruyter.com/view/journals/pp/pp-overview.xml

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