mBio (Oct 2021)

Identification of ZDHHC17 as a Potential Drug Target for Swine Acute Diarrhea Syndrome Coronavirus Infection

  • Yun Luo,
  • Chee Wah Tan,
  • Shi-Zhe Xie,
  • Ying Chen,
  • Yu-Lin Yao,
  • Kai Zhao,
  • Yan Zhu,
  • Qi Wang,
  • Mei-Qin Liu,
  • Xing-Lou Yang,
  • Lin-Fa Wang,
  • Zheng-Li Shi

DOI
https://doi.org/10.1128/mBio.02342-21
Journal volume & issue
Vol. 12, no. 5

Abstract

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The recent emergence of deadly zoonotic viral diseases, including Ebola virus and SARS-CoV-2, emphasizes the importance of pandemic preparedness for the animal-sourced viruses with potential risk of animal-to-human spillover. Over the last 2 decades, three significant coronaviruses of bat origin, SARS-CoV, MERS-CoV, and SARS-CoV-2, have caused millions of deaths with significant economy and public health impacts.