Organophotocatalytic dearomatization of indoles, pyrroles and benzo(thio)furans via a Giese-type transformation

Yueteng Zhang; Peng Ji; Feng Gao; Yue Dong; He Huang; Changqing Wang; Ziyuan Zhou; Wei Wang

doi:10.1038/s42004-021-00460-y

Communications Chemistry (Feb 2021)

Organophotocatalytic dearomatization of indoles, pyrroles and benzo(thio)furans via a Giese-type transformation

Yueteng Zhang,
Peng Ji,
Feng Gao,
Yue Dong,
He Huang,
Changqing Wang,
Ziyuan Zhou,
Wei Wang

Affiliations

Yueteng Zhang: Departments of Pharmacology and Toxicology and Chemistry and Biochemistry, and BIO5 Institute, University of Arizona
Peng Ji: Departments of Pharmacology and Toxicology and Chemistry and Biochemistry, and BIO5 Institute, University of Arizona
Feng Gao: Departments of Pharmacology and Toxicology and Chemistry and Biochemistry, and BIO5 Institute, University of Arizona
Yue Dong: Departments of Pharmacology and Toxicology and Chemistry and Biochemistry, and BIO5 Institute, University of Arizona
He Huang: Department of Chemistry and Chemical Biology, Cornell University
Changqing Wang: Departments of Pharmacology and Toxicology and Chemistry and Biochemistry, and BIO5 Institute, University of Arizona
Ziyuan Zhou: National Clinical Research Centre for Infectious Diseases, Shenzhen Third People’s Hospital, The Second Hospital Affiliated to Southern University of Science and Technology
Wei Wang: Departments of Pharmacology and Toxicology and Chemistry and Biochemistry, and BIO5 Institute, University of Arizona

DOI: https://doi.org/10.1038/s42004-021-00460-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

Read online

Dearomatisation of indoles allows efficient access to indolines, but often is incompatible with electron-withdrawing substituents. Here a photoredox Giese-type dearomatisation of indoles yields 2,3-disubstituted indolines bearing electron-withdrawing groups.

Published in Communications Chemistry

ISSN: 2399-3669 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.nature.com/commschem

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