Clinical Improvement, Disease recurrence, and Patient Satisfaction Following Treatment with Vaginal Effervescent Tablets of Tranexamic Acid and Cryotherapy in Patients with Symptomatic Cervical Ectropions: A Randomized Controlled Trial

Abstract

Background & aim: Cervical ectropion refers to a condition in which the cylindrical epithelium of the endocervix extends towards the ectocervix. The present study was conducted to compare clinical improvement, disease recurrence, and patient satisfaction following treatment with vaginal effervescent tablets of tranexamic acid and cryotherapy in patients with symptomatic cervical ectropions.Methods: This randomized clinical trial was conducted on 92 women with symptomatic cervical ectropions from March 2021 until September 2022 at Ayatollah Mousavi Hospital in Zanjan. Sampling was done at first step by convenience sampling, and then randomly assigning the sample to two groups: an intervention group receiving 400 mg of vaginal effervescent tranexamic acid tablets for 10 days and a comparison group with cryotherapy. At the end of the third month of the intervention, the rate of clinical improvement, disease recurrence, and patient satisfaction were evaluated in both groups. Data analysis was performed by SPSS software (version 22) using Chi-square and Fisher's exact tests.Results: At the end of the intervention, 97.72% and 93.18% of the participants reported improvement in clinical symptoms following tranexamic acid and cryotherapy, respectively. There was no statistically significant difference between the two groups in terms of clinical improvement (P = 0.31), disease recurrence (P = 0.64), and patient satisfaction (P = 0.57).Conclusion:Considering the similar effectiveness of tranexamic acid and cryotherapy in improving the clinical symptoms of patients, this method can be a suitable alternative to cryotherapy.

Keywords

• tranexamic acid
• cryotherapy
• patient satisfaction randomized controlled trial