Adult-onset adrenoleukodystrophy presenting as a psychiatric disorder: MRI findings

Abstract

ABSTRACT A 35-year-old, previously healthy man presented psychiatric symptoms lasting four years, receiving treatment with neuroleptics. One year later he evolved with gait disequilibrium. After a further six months, cognitive symptoms were characterized with rapid evolution to a profound demented state. MRI showed signal changes in cerebral white matter and very long-chain fatty acids were detected in blood.

Keywords

• leukoencephalopathies
• leukodystrophies
• adult-onset adrenoleukodystrophy
• magnetic resonance imaging