Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers

Xiaoran Duan; Tao Huang; Daping Zhang; Yujie Wei; Lifeng Li; Wu Yao; Liuxin Cui; Xiaoshan Zhou; Yongli Yang; Wei Wang; Jie Zhao

Ecotoxicology and Environmental Safety (Jan 2023)

Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers

Xiaoran Duan,
Tao Huang,
Daping Zhang,
Yujie Wei,
Lifeng Li,
Wu Yao,
Liuxin Cui,
Xiaoshan Zhou,
Yongli Yang,
Wei Wang,
Jie Zhao

Affiliations

Xiaoran Duan: National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, China; Medical School, Huanghe Science and Technology University, Zhengzhou, Henan, China; Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Tao Huang: Medical School, Huanghe Science and Technology University, Zhengzhou, Henan, China
Daping Zhang: Department of Cardiology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China
Yujie Wei: National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, China
Lifeng Li: National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, China
Wu Yao: Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Liuxin Cui: Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Xiaoshan Zhou: Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Yongli Yang: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Wei Wang: Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China; Correspondence to: Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, No.100Kexue Road, Zhengzhou, 450001, China. Fax: 86-371-67781466.
Jie Zhao: National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, China; Correspondence to: The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road, Erqi District, Zhengzhou, 450052, China. Fax: 86-371-67966215.

Journal volume & issue: Vol. 250
p. 114489

Abstract

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Coke oven emissions (COEs) contain many carcinogenic polycyclic aromatic hydrocarbons (PAHs). Telomere damage is an early biological marker reflecting long-term COEs-exposure. Whereas, whether the genetic variations of telomere-regulated gene TNKS have an effect on the COEs-induced telomere damage is unknown. So we detected the environmental exposure levels, relative telomere length (RTL), and TNKS genetic polymorphisms among 544 COEs-exposure workers and 238 healthy participants. We found that the RTL of the wild homozygous GG genotype in rs1055328 locus was statistically shorter compared with the CG+CC genotype for the healthy participants using covariance analysis(P = 0.008). In the Generalized linear model (GLM) analysis, TNKS rs1055328 GG could accelerate telomere shortening (P = 0.011); and the interaction between TNKS rs1055328 GG and COEs-exposure had an effect on RTL (P = 0.002). In conclusion, this study was the first to discover the role of TNKS rs1055328 locus in COEs-induced telomere damage, and proved that chromosomal damage was a combined consequence of environmental and genetic factors.

Published in Ecotoxicology and Environmental Safety

ISSN: 0147-6513 (Print); 1090-2414 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Technology: Environmental technology. Sanitary engineering: Environmental pollution; Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/ecotoxicology-and-environmental-safety

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