Supramolecular design based activatable magnetic resonance imaging
Wen‐Chao Geng,
Zhe Zheng,
Dong‐Sheng Guo
Affiliations
Wen‐Chao Geng
College of Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) State Key Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin P. R. China
Zhe Zheng
College of Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) State Key Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin P. R. China
Dong‐Sheng Guo
College of Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) State Key Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin P. R. China
Abstract Magnetic resonance imaging (MRI) has been widely used in clinical diagnosis. In recent years, activatable MRI probes responding to specific changes in their microenvironment have been developed. The signal of the MRI probe can be modulated based on supramolecular design, which can include properties such as self‐assembly and molecular recognition. In this review, we summarize the activatable MRI probes based on the design principles of supramolecular chemistry. We also discuss the current challenges and the future perspectives for how activatable MRI can achieve more extensive clinical applications for cancer therapy.
