Gynecology Obstetrics & Reproductive Medicine (Apr 2011)

Galectin-3 Expression in Human Endometrium and Decidua During The Menstrual Cycle and in Gestation

  • Nevra Dursun,
  • Melin Özgün Geçer,
  • Pelin Yıldız,
  • Cem Leblebıcı,
  • Erol Rüştü Bozkurt,
  • Nimet Karadayı,
  • Fadime Bahadır

Journal volume & issue
Vol. 17, no. 1

Abstract

Read online

OBJECTIVE: G3 is one of the members of the lectin family that may be involved in the establishment of endometrial receptivity by regulating the proliferation and adhesion of endometrial cells. STUDY DESIGN: Immunohistochemical expression of G3 was tested in late secretory phase of the endometrium (SPE)(n=30), proliferative phase of the endometrium (PPE)(n=34), and decidua (n=41) and induced abortions in the first trimester. RESULTS: Expression of G3 during the PPE was low; 12 cases were score 1 and 19 cases were score 2 (p<0.001). However, among the late SPE, there were 11 cases at score 2, and 15 cases at score 3. In the decidua expression of G3, 37 cases were score 3 (p<0.001). CONCLUSION: There is a significant progression of G3 expression in SPE and gestation. Although during the PPE expression is considerably lower. This shows that G3 plays an important role in implantation.

Keywords