Nature Communications (Nov 2022)
Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter
- M. Kalindu D. Rodrigo,
- Aarti Saiganesh,
- Andrew J. Hayes,
- Alisha M. Wilson,
- Jack Anstey,
- Janessa L. Pickering,
- Jua Iwasaki,
- Jessica Hillas,
- Scott Winslow,
- Tabitha Woodman,
- Philipp Nitschke,
- Jake A. Lacey,
- Karen J. Breese,
- Mark P. G. van der Linden,
- Philip M. Giffard,
- Steven Y. C. Tong,
- Nicola Gray,
- Keith A. Stubbs,
- Jonathan R. Carapetis,
- Asha C. Bowen,
- Mark R. Davies,
- Timothy C. Barnett
Affiliations
- M. Kalindu D. Rodrigo
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Aarti Saiganesh
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Andrew J. Hayes
- Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Alisha M. Wilson
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Jack Anstey
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Janessa L. Pickering
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Jua Iwasaki
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Jessica Hillas
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Scott Winslow
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Tabitha Woodman
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Philipp Nitschke
- Australian National Phenome Centre and the Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University
- Jake A. Lacey
- Department of Infectious Diseases at the Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Karen J. Breese
- School of Molecular Sciences, University of Western Australia
- Mark P. G. van der Linden
- German National Reference Center for Streptococci, Institute of Medical Microbiology, University Hospital RWTH Aachen
- Philip M. Giffard
- Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University
- Steven Y. C. Tong
- Department of Infectious Diseases at the Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Nicola Gray
- Australian National Phenome Centre and the Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University
- Keith A. Stubbs
- School of Molecular Sciences, University of Western Australia
- Jonathan R. Carapetis
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Asha C. Bowen
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- Mark R. Davies
- Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Timothy C. Barnett
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia
- DOI
- https://doi.org/10.1038/s41467-022-34243-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
There is increasing evidence for metabolic processes mediating antimicrobial resistance. Here, the authors present a mechanism of sulfamethoxazole resistance in Group A Streptococcus that is dependent on acquiring end products of the host folate biosynthesis pathway.
