Frontiers in Virology (May 2022)
Role of the HIV-1 Reservoir to Maintain Viral Suppression in a Simplified Strategy for the Long-Term Management of HIV-1 Infection (The SIMPL’HIV Trial)
- Mattia Branca,
- Annalisa Marinosci,
- Delphine Sculier,
- Delphine Sculier,
- Gilles Wandeler,
- Gilles Wandeler,
- Sabine Yerly,
- Marcel Stoeckle,
- Enos Bernasconi,
- Dominique L. Braun,
- Dominique L. Braun,
- Kathrin Neumann,
- Kathrin Neumann,
- Pietro Vernazza,
- Matthias Cavassini,
- Marta Buzzi,
- Laurent A. Decosterd,
- Patrick Schmid,
- Andreas Limacher,
- Huldrych F. Günthard,
- Huldrych F. Günthard,
- Karin J. Metzner,
- Karin J. Metzner,
- Alexandra Calmy
Affiliations
- Mattia Branca
- CTU Bern, University of Bern, Bern, Switzerland
- Annalisa Marinosci
- HIV/AIDS Unit, Department of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland
- Delphine Sculier
- HIV/AIDS Unit, Department of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland
- Delphine Sculier
- Private Practice Office, Geneva, Switzerland
- Gilles Wandeler
- Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland
- Gilles Wandeler
- Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
- Sabine Yerly
- Laboratory of Virology, Geneva University Hospitals, Geneva, Switzerland
- Marcel Stoeckle
- Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, University of Basel, Basel, Switzerland
- Enos Bernasconi
- Division of Infectious Diseases, Regional Hospital of Lugano, Lugano, Switzerland
- Dominique L. Braun
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
- Dominique L. Braun
- 0Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Kathrin Neumann
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
- Kathrin Neumann
- 0Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Pietro Vernazza
- 1Division of Infectious Diseases and Hospital Epidemiology, Kantonspital St. Gallen, St. Gallen, Switzerland
- Matthias Cavassini
- 2Department of Infectious Diseases, Lausanne University Hospital, Lausanne, Switzerland
- Marta Buzzi
- HIV/AIDS Unit, Department of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland
- Laurent A. Decosterd
- 3Pharmacology Laboratory, Clinical Pharmacology Department, University of Lausanne, Lausanne, Switzerland
- Patrick Schmid
- 1Division of Infectious Diseases and Hospital Epidemiology, Kantonspital St. Gallen, St. Gallen, Switzerland
- Andreas Limacher
- CTU Bern, University of Bern, Bern, Switzerland
- Huldrych F. Günthard
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
- Huldrych F. Günthard
- 0Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Karin J. Metzner
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
- Karin J. Metzner
- 0Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Alexandra Calmy
- HIV/AIDS Unit, Department of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland
- DOI
- https://doi.org/10.3389/fviro.2022.855437
- Journal volume & issue
-
Vol. 2
Abstract
HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simplified maintenance antiretroviral therapy in chronically HIV-1 infected patients. In the SIMPL’HIV trial, HIV-1 DNA was quantified in peripheral blood mononuclear cells obtained at baseline and week 48 to investigate changes over time and evidence of a predictive relationship to maintain HIV-1 RNA <20 copies/ml. Measurements were available for 175 patients, with no differences observed between treatment strategies. Findings showed that baseline HIV-1 DNA was lower in those with durable HIV-1 RNA <20 copies/ml compared with patients with incomplete viral suppression over 48 weeks.
Keywords
